Endocrine Abstracts

Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs along with FGF19 and 21 to a subfamily of endocrine FGFs with evolutionary conserved functions, which can be demonstrated in the gut of C. elegans and in the kidney tubules of fruit flies. FGF23 is posttranslationally regulated by phosphorylation through FAM20C, which causes its proteolysis through the subtilisin-like proprotein convertase FURIN, and results in secretion of FGF23 fragments. O-glycosyla...